Nervousness, misery frequent amongst caregivers of sufferers with a number of myeloma

The Mary Sanderson Fund supported the research. The authors report no related monetary disclosures.

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Caregivers of sufferers with a number of myeloma reported vital psychological misery throughout the most cancers care continuum in contrast with sufferers themselves, based on research outcomes revealed in Blood Advances.

Rationale and strategies

“This research was prompted by my expertise offering look after sufferers and caregivers as they undergo their myeloma journey,” Elizabeth O’Donnell, MD, medical oncologist at Massachusetts Basic Hospital, advised Healio. “It was my need to higher perceive the misery that I perceived in order that we may then strive make the expertise of being handled for myeloma higher.”

More caregivers reported higher rates of clinically significant anxiety compared with patients (44.4% vs. 22.5%)

O’Donnell E, et al. Blood Adv. 2022;doi:10.1182/bloodadvances.2022007127.

The cross-sectional, multisite research included 180 sufferers present process therapy for a number of myeloma throughout the Dana-Farber/Harvard Most cancers Heart Community between June 2020 and January 2021, in addition to 127 of their caregivers.

Elizabeth O'Donnell

Elizabeth O’Donnell

Researchers included 43 caregivers of sufferers newly recognized with a number of myeloma, 40 of sufferers who obtained two to 3 strains of remedy, and 44 of sufferers who obtained 4 or extra strains of remedy. The caregivers accomplished a validated questionnaire that assessed high quality of life, psychological misery and perceptions of prognosis.

Key findings

Outcomes confirmed 44.1% of caregivers skilled clinically vital signs of tension, 15.8% had signs of despair and 24.4% had signs of PTSD.

When examined in pairs, researchers discovered a better proportion of caregivers vs. sufferers reported clinically vital nervousness (44.4% vs. 22.5%).

“It was significantly attention-grabbing to study that the degrees of tension had been increased in caregivers than sufferers,” O’Donnell advised Healio. “These outcomes weren’t stunning, however they’ve supplied a extra concrete sense of the scope of emotional misery and supplied benchmarks for the degrees of tension, despair and PTSD amongst our caregivers for future interventions.”

Though 84.2% of caregivers reported that the oncologist had advised them the affected person’s most cancers was incurable, solely 50.9% of caregivers acknowledged the terminal nature of the illness and 53.6% acknowledged the most cancers was incurable.


This research underscores the necessity to make sure that well being care suppliers are speaking with sufferers and their caregivers about prognosis as a result of each sufferers and caregivers strongly need details about prognosis, O’Donnell mentioned.

“The emotional experiences of each sufferers and caregivers are an necessary consideration in most cancers therapy,” she added. “A number of myeloma suppliers want to pay attention to the prevalence of emotional misery of each their sufferers and their caregivers. Future analysis must deal with interventions that may mitigate the misery of present process remedy for a number of myeloma.”

For extra info:

Elizabeth O’Donnell, MD, may be reached at


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